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Impact de La Proteine C Activee Dans Le Sepsis by Bruel Cedric (Paperback / softback, 2012)

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Product Information

Veritable probleme de sante publique, le sepsis demeure depuis plusieurs decennies une des causes les plus frequentes d'admission en reanimation. Sa morbi-mortalite importante a contraint les praticiens a developper de uvelles strategies therapeutiques. La proteine C activee fait partie de ce uvel arsenal, en reponse aux perturbations de la coagulation et de la fibrilyse induite par le sepsis. La consommation excessive de cet anticoagulant naturel au cours du sepsis est correlee a une augmentation de la mortalite. Partant de ces connaissances, la drotrecogine alfa (activee) a ete produite par genie genetique. L'etude pivot PROWESS a permis de valider l'efficacite et la tolerance de cette molecule, et par voie de consequence, d'obtenir son AMM dans le sepsis severe associe a deux defaillances d'organe. Ce travail propose une etude retrospective, cas-temoin, parmi un echantillon de 27 patients admis en choc septique au CHU de Caen dont 14 qui ont beneficie de ce traitement adjuvant. Quatre deces etaient constates a J28 mais aucun syndrome hemorragique imputable a la drotrecogine alfa n'etait a deplorer.

Product Identifiers

Publisher
Academiques
ISBN-10
3838175441
ISBN-13
9783838175447
eBay Product ID (ePID)
190480461

Product Key Features

Author
Bruel Cedric
Format
Paperback / Softback, Trade Paperback (US) ,Unsewn / Adhesive Bound
Language
French
Subject
Medicine: General
Type
Textbook

Additional Product Features

Series Title
Omn.Pres.Franc.
Content Note
Black & White Illustrations
Date of Publication
31/10/2012
Country of Publication
United States

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