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Protective Groups in Organic Chemistry by J.F.W. McOmie (Hardcover, 1973)

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During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.

Product Identifiers

Publisher
Springer
ISBN-13
9780306307171
eBay Product ID (ePID)
103186976

Product Key Features

Author
J.F.w. Mcomie
Publication Name
Protective Groups in Organic Chemistry
Format
Hardcover
Language
English
Subject
Chemistry
Publication Year
1973
Type
Textbook
Number of Pages
429 Pages

Dimensions

Item Height
250mm
Item Width
160mm

Additional Product Features

Editor
J.F.w. Mcomie
Country/Region of Manufacture
United Kingdom

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Protective Groups in Organic Chemistry by J.F.W. McOmie (Hardcover, 1973)

About this product

Product Information

Product Identifiers

Product Key Features

Dimensions

Additional Product Features

Best Selling in Adult Learning & University

Time Management by Peter Quarry (Paperback, 1986)

Silent Spring by Rachel Carson (Paperback, 2000)

Complete Illustrated Encyclopedia of Dinosaurs & Prehistoric Creatures by Dixon Dougal (Paperback, 2014)

Thunder of Hooves: A History of 12 Light Horse Regiment 1915-1919 by Kenneth Hollis (Hardcover, 2008)

Polyvagal Exercises for Safety and Connection: 50 Client-Centered Practices by Deb Dana (Paperback, 2020)

On Killing: The Psychological Cost of Learning to Kill in War and Society by Dave Grossman (Paperback, 2009)

Save on Adult Learning & University

It's Not You: How to Identify and Heal from NARCISSISTIC People by Ramani Durvas

Ford Falcon EF EL / Fairlane NF NL 1994 - 1998 Workshop Manual

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